Cholesterol: Size Matters!

Cholesterol: Size Matters!

Cardiovascular disease, in which the principal manifestation is coronary heart disease, remains the single leading cause of death and disability worldwide. If you’re one of the many people with high cholesterol, you may have been prescribed statin drugs and told to eat a low-fat diet — the standard advice for

decades. However, experts have now reviewed the research and found there is no link between heart disease and total fat, saturated fat, or dietary cholesterol.

Statins  

Cholesterol-lowering statins are among the most commonly prescribed medications in the world, taken by 25 percent of people over age 45. Touted to keep heart disease at bay, statin drugs are now known to be a cause of serious memory loss, fuzzy thinking, learning difficulties, fatigue, muscle damage, and even diabetes.

Why do statins cause memory loss? The human brain is made up of 60 percent fat, much of that is cholesterol. The brain uses cholesterol to build brain chemicals that allow neurons to communicate with one another. Without cholesterol, the brain’s cells eventually die from inactivity. Over time, this results in memory loss and other brain disorders. In studies of the elderly, those with high total cholesterol actually have reduced risk of dementia – likely due to their body’s plentiful supply of this brain-supporting substance.

Cholesterol and heart attack risk

In a review of 72 studies, researchers found that most heart attack patients’ cholesterol levels did not indicate cardiac risk; in fact, 75 percent of them had normal, not high, LDL (“bad”) cholesterol. Even more surprising, 90 percent of them had HDL (“good”) cholesterol levels under 60. Additionally, low HDL is a warning sign for pre-diabetes, and most of these patients had pre-diabetes or “metabolic syndrome.” We now know that low HDL, not high LDL, is the real driver behind most heart attacks and heart diseases, which changes the game on cholesterol management.

What about dietary fat?

Consider the following regarding low-fat diets. (Keep in mind this refers to the intake of healthy fats):

High-fat diets lower triglycerides, normalize LDL (bad cholesterol) and increase LDL particle size. LDL cholesterol comes in two sizes; large particles that move freely, causing no harm, and small particles that embed in artery walls, causing inflammation and the buildup of plaque. You want fluffy large particles.

The National Institutes of Health reported that increasing fat intake to 50 percent of calories improved the nutritional status of heart study participants and didn’t negatively affect heart disease risk factors.

The 2015 U.S. Dietary Guidelines Advisory Committee reviewed all the research over 40 years and told us to stop worrying about dietary cholesterol, arguing it is “not a nutrient of concern for overconsumption.”

Can my cholesterol be too low?

People who consume low-fat diets are at increased risk for depression and suicide (remember how the brain is made from 60 percent fat).

And here’s the clincher: Harvard School of Public Health recently admitted that when it comes to disease prevention, low-fat diets don’t appear to offer any special benefits. It’s sugar and refined carbohydrates that contribute to obesity, pre-diabetes, heart disease, and many other health issues.

If not fat, what causes heart disease?

Here are five important factors in heart disease risk:

  • Inflammation in the body.
  • Free radicals attack LDL and turn it from large (unharmful) into small (harmful) particles.
  • Trans fats increase inflammation and raise triglycerides.
  • Sugar, which is inflammatory, promotes plaque formation in arteries and raises stress hormones.
  • Stress increases blood pressure and causes other health issues.

Tests available

Lipoproteins are made up of fat and proteins. LDL means low-density lipoprotein, and HDL stands for high-density lipoprotein.  Lipoprotein subfractionation tells you the size and number of particles that make up lipoproteins in your blood (small particle size LDL = bad). This test gives your doctor more information about your risk for heart disease and stroke. It may also help you find out if the things you are doing to balance your cholesterol are working or if you need to change strategies.

Smoking, high blood pressure, diabetes, and food sensitivities may all lead to swelling in the arteries. This inflammation can lead to a heart attack or stroke. High sensitivity C reactive protein (hs-CRP) and Lp-PLAare advanced blood tests that measure the amount of inflammation within the arteries.

Work with your doctor to set up the best strategies for long-term health and work to decrease your chances of developing cardiovascular disease.